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Glycosylation eases muscular dystrophy

Nature Medicine volume 10, pages 676–677 (2004)Cite this article

Several forms of muscular dystrophy are associated with mutations in genes that regulate glycosylation of α-dystroglycan. Forced overexpression of one of these genes, LARGE, in mice overcomes the defective glycosylation present in this group of disorders (pages 696–703).

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Figure 1: Intracellular and extracellular events leading to a functional α-dystroglycan receptor.

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Authors and Affiliations

  1. Department of Pediatrics, Dubowitz Neuromuscular Centre, Imperial College, Hammersmith Campus, London, UK

    Francesco Muntoni, Martin Brockington & Susan C Brown

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  1. Francesco Muntoni
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  2. Martin Brockington
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  3. Susan C Brown
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Muntoni, F., Brockington, M. & Brown, S. Glycosylation eases muscular dystrophy. Nat Med 10, 676–677 (2004). https://doi.org/10.1038/nm0704-676

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