Autoantibodies to group A streptococcocal sugar moieties are now implicated in Sydenham chorea, a neuropsychiatric complication of rheumatic fever. These antibodies appear to disturb neuronal cell function by binding to glycolipids (pages 914–920).
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References
Husby, G., van de Rijn, I., Zabriskie, J.B., Abdin, Z.H. & Williams, R.C. Jr. Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J. Exp. Med. 144, 1094–1110 (1976).
Swedo, S.E. et al. High prevalence of obsessive-compulsive symptoms in patients with Sydenham's chorea. Am. J. Psychiatry 146, 246–249 (1989).
Kirvan, C.A., Swedo, S.E., Heuser, J.S. & Cunningham, M.W. Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea. Nat. Med. 9, 914–920 (2003).
Giedd, J.N. et al. Sydenham's chorea: magnetic resonance imaging of the basal ganglia. Neurology 45, 2199–2202 (1995).
Hollander, E. et al. B lymphocyte antigen D8/17 and repetitive behaviors in autism. Am. J. Psychiatry 156, 317–320 (1999).
Comi, A.M., Zimmerman, A.W., Frye, V.H., Law, P.A. & Peeden, J.N. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J. Child Neurol. 14, 388–394 (1999).
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Fujinami, R., Sweeten, T. Letting antibodies get to your head. Nat Med 9, 823–825 (2003). https://doi.org/10.1038/nm0703-823
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DOI: https://doi.org/10.1038/nm0703-823