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Angiogenesis inhibitors: motivators of metastasis?

Angiogenesis inhibitors have shown promise in hindering blood supply and holding tumors in check. But it now seems that such inhibitors, by depriving tumors of oxygen, could have an unintended effect: promotion of metastasis.

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Figure 1: Oxygen-deprived and dangerous.

Reprinted with permission from Elsevier Science

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Steeg, P. Angiogenesis inhibitors: motivators of metastasis?. Nat Med 9, 822–823 (2003). https://doi.org/10.1038/nm0703-822

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