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Elevated plasma ghrelin levels in Prader–Willi syndrome

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Figure 1: Obesity from PWS is associated with high circulating ghrelin levels.


  1. 1

    Barsh, G.S., Farooqi, I.S. & O'Rahilly, S. Genetics of body-weight regulation. Nature 404, 644–651 (2000).

    CAS  Article  Google Scholar 

  2. 2

    Clement, K. et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398–401 (1998).

    CAS  Article  Google Scholar 

  3. 3

    Vaisse, C. et al. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J. Clin. Invest. 106, 253–262 (2000).

    CAS  Article  Google Scholar 

  4. 4

    Kojima, M. et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656–660 (1999).

    CAS  Article  Google Scholar 

  5. 5

    Tschop, M., Smiley, D.L. & Heiman, M.L. Ghrelin induces adiposity in rodents. Nature 407, 908–913 (2000).

    CAS  Article  Google Scholar 

  6. 6

    Nakazato, M. et al. A role for ghrelin in the central regulation of feeding. Nature 409, 194–198 (2001).

    CAS  Article  Google Scholar 

  7. 7

    Inui, A. Ghrelin: An orexigenic and somatotrophic signal from the stomach. Nature Rev. Neurosci. 2, 551–560 (2001).

    CAS  Article  Google Scholar 

  8. 8

    Cummings, D.E. et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50, 1714–1719 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Cummings, D.E. et al. Human plasma ghrelin levels after diet-induced weight loss and gastric bypass surgery. New Engl. J. Med. 346, 1623–1630 (2002).

    Article  Google Scholar 

  10. 10

    Wren, A.M. et al. Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86, 5992–5995 (2001).

    CAS  Article  Google Scholar 

  11. 11

    Burman, P., Ritzen, E.M. & Lindgren, A.C. Endocrine dysfunction in Prader-Willi syndrome: A review with special reference to GH. Endocr. Rev. 22, 787–799 (2001).

    CAS  Article  Google Scholar 

  12. 12

    Nicholls, R.D. & Knepper, J.L. Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes. Annu. Rev. Genomics Hum. Genet. 2, 153–175 (2001).

    CAS  Article  Google Scholar 

  13. 13

    Dubern, B. et al. Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children. J. Pediatr. 139, 204–209 (2001).

    CAS  Article  Google Scholar 

  14. 14

    Janssen, J.A. et al. Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy. Eur J Endocrinol 145, 711–716 (2001).

    CAS  Article  Google Scholar 

  15. 15

    Asakawa, A. et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120, 337–345 (2001).

    CAS  Article  Google Scholar 

  16. 16

    Weigle, D.S. et al. Effect of regional fat distribution and Prader-Willi syndrome on plasma leptin levels. J. Clin. Endocrinol. Metab. 82, 566–570 (1997).

    CAS  PubMed  Google Scholar 

  17. 17

    Wren, A.M. et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes 50, 2540–2547 (2001).

    CAS  Article  Google Scholar 

  18. 18

    Rittmaster, R.S., Loriaux, D.L. & Merriam, G.R. Effect of continuous somatostatin and growth hormone-releasing hormone (GHRH) infusions on the subsequent growth hormone (GH) response to GHRH: Evidence for somatotroph desensitization independent of GH pool depletion. Neuroendocrinology 45, 118–122 (1987).

    CAS  Article  Google Scholar 

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Cummings, D., Clement, K., Purnell, J. et al. Elevated plasma ghrelin levels in Prader–Willi syndrome. Nat Med 8, 643–644 (2002).

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