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Minor antigen solves major problem

Nature Medicine volume 7, pages 769–770 (2001)Cite this article

A mouse model for donor lymphocyte infusion reveals that a single immunodominant minor H antigen is responsible for the beneficial effects of donor T lymphocytes against host leukemia. Separating the good from the bad could mean the end of graft-versus-host disease in bone marrow transplants. (pages 789–794)

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Figure 1: The infusion of T cells directed against multiple minor H antigen differences produces severe GvHD (left).

Stephen Horwitz

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Authors and Affiliations

  1. Department of Haematology, Imperial College School of Medicine Hammersmith Hospital, London, UK

    Francesco Dazzi & John M Goldman

  2. Transplantation Biology, Imperial College School of Medicine Hammersmith Hospital, London, UK

    Elizabeth Simpson

  3. Francesco Dazzi

Authors
  1. Francesco Dazzi
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  2. Elizabeth Simpson
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  3. John M Goldman
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Dazzi, F., Simpson, E. & Goldman, J. Minor antigen solves major problem. Nat Med 7, 769–770 (2001). https://doi.org/10.1038/89874

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