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Dengue virus and dendritic cells

Nature Medicine volume 6, pages 748–749 (2000)Cite this article

Little is known about the pathogenesis of the Dengue virus, a mosquito-borne flavivirus that causes about 50 million human infections annually, some of which may be fatal. Recent studies have demonstrated two subsets of dendritic cells, monocyte-derived dendritic cells and human skin Langerhans cells, that are targets for Dengue virus infection (pages 816–820).

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Figure 1: Precursors of dendritic cells circulate in the blood.

References

  1. Steinman, R.M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271–296 (1991).

    Article  CAS  Google Scholar 

  2. Banchereau, J. et al. Immunobiology of dendritic cells. Ann. Rev. Immunol. 18, 767 (2000).

    Article  CAS  Google Scholar 

  3. Caux, C. et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor α: II. Functional analysis. Blood 90, 1458– 1470 (1997).

    CAS  PubMed  Google Scholar 

  4. Ferlazzo, G., Klein, J., Paliard, X., Wei, W.Z. & Galy, A. Dendritic cells generated from CD34+ progenitor cells with flt3 ligand, c-kit ligand, GM-CSF, IL-4, and TNF-α are functional antigen-presenting cells resembling mature monocyte-derived dendritic cells. J. Immunother. 23, 48–58 ( 2000).

    Article  CAS  Google Scholar 

  5. Siegal, F.P. et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 284, 1835– 1837 (1999).

    Article  CAS  Google Scholar 

  6. Geijtenbeek, T.B. et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100, 587–597 (2000).

    Article  CAS  Google Scholar 

  7. Grosjean, I. et al. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells. J. Exp. Med. 186, 801–812 (1997).

    Article  CAS  Google Scholar 

  8. Wu, S. et al. Human skin Langerhans cells are targets of dengue virus infection . Nature Med. 6, 816–820 (2000).

    Article  CAS  Google Scholar 

  9. Monath, T. in Infectious diseases (eds. Mandell, G.L., Douglas, R.G.Jr. & Bennett, J.E.) (Churchill Livingstone, NY, 1990).

    Google Scholar 

  10. Velzing, J. et al. Induction of protective immunity against Dengue virus type 2: comparison of candidate live attenuated and recombinant vaccines. Vaccine 17, 1312–1320 ( 1999).

    Article  CAS  Google Scholar 

  11. Gagnon, S., Ennis, F. & Rothman, A. Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones. J. Virol. 73, 3623–3629 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Kurane, I., Meager, A. & Ennis, F. Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production and cytotoxic activity. J. Exp. Med. 170, 763–775 (1989).

    Article  CAS  Google Scholar 

  13. Huang, J. et al. Antibody responses to an immunodominant nonstructural 1 synthetic peptide in patients with dengue fever and dengue hemorrhagic fever. J. Med. Virol. 57, 1–8 ( 1999).

    Article  CAS  Google Scholar 

Download references

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  1. Baylor Institute for Immunology Research Dallas,, 75204, Texas, USA

    Anna Karolina Palucka

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Palucka, A. Dengue virus and dendritic cells. Nat Med 6, 748–749 (2000). https://doi.org/10.1038/77470

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