The how and Y of eating

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Knockout mice reveal a complex role for neuropeptide Y receptors Y1 and Y5 in feeding behavior (pages 718–721 and 722–726).

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References

  1. 1

    Turton, M.D., O'Shea, D. & Bloom, S.R. Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes. In Neuropeptide Y and drug development (eds. Grundemar, L. & Bloom, S.R.) 15–39 (Academic Press, London, 1997).

  2. 2

    Kalra, S.P. Appetite and body weight regulation: is it all in the brain. Neuron 19, 227–230 (1997).

  3. 3

    Rohner-Jeanrenaud, F., Cusin, I., Sainsbury, A., Zakrzewska, E. & Jeanrenaud, B. The loop system between neuropeptide Y and leptin in normal and obese rodents. Horm, Metab. Res. 28, 642–648 (1996).

  4. 4

    O'Shea, D. et al. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology 138, 196–202 (1997).

  5. 5

    Gerald, C. et al. A receptor subtype involved in neuropeptide Y-induced food intake. Nature 382, 168–171 (1996).

  6. 6

    Larsen, P.J., Sheikh, S.P., Schwartz, T.W., Rehfeld-Jacobsen, C. & Mikkelsen, J.D. Regional distribution of putative NPY Yl receptors in forebrain areas of the rat central nervous system. Eur. J. Neurosci. 5, 1622–1637 (1993).

  7. 7

    Schaffhauser, A.O. et al. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes 46, 1792–1798 (1997).

  8. 8

    Pedrazzini, T. et al. Cardiovascular response, feeding behaviour, and locomotor activity in mice lacking the NPY Yl receptor. Nature Med. 4, 722–726 (1998).

  9. 9

    Marsh, D.J., Hollopeter, G., Kafer, K.E. & Palmiter, R.D. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nature Med. 4, 718–721 (1998).

  10. 10

    Erickson, J.C., Clegg, K.E. & Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures in mice lacking neuropeptide Y. Nature 381, 415–118 (1996).

  11. 11

    Broberger, C., Landry, M., Wong, H., Walsh, J.N. & Hökfelt, T. Subtypes of Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66, 393–408 (1997).

  12. 12

    Erickson, J.C., Hollopeter, G. & Palmiter, R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274, 1704–1707 (1996).

  13. 13

    Stephens, T.W. et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530–532 (1995).

  14. 14

    Herzog, H. et al. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics 41, 315–319 (1997).

  15. 15

    Wahlestedt, C. et al. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259, 528–531 (1993).

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Woldbye, D., Larsen, P. The how and Y of eating. Nat Med 4, 671–672 (1998) doi:10.1038/nm0698-671

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