Knockout mice reveal a complex role for neuropeptide Y receptors Y1 and Y5 in feeding behavior (pages 718–721 and 722–726).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Turton, M.D., O'Shea, D. & Bloom, S.R. Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes. In Neuropeptide Y and drug development (eds. Grundemar, L. & Bloom, S.R.) 15–39 (Academic Press, London, 1997).
Kalra, S.P. Appetite and body weight regulation: is it all in the brain. Neuron 19, 227–230 (1997).
Rohner-Jeanrenaud, F., Cusin, I., Sainsbury, A., Zakrzewska, E. & Jeanrenaud, B. The loop system between neuropeptide Y and leptin in normal and obese rodents. Horm, Metab. Res. 28, 642–648 (1996).
O'Shea, D. et al. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology 138, 196–202 (1997).
Gerald, C. et al. A receptor subtype involved in neuropeptide Y-induced food intake. Nature 382, 168–171 (1996).
Larsen, P.J., Sheikh, S.P., Schwartz, T.W., Rehfeld-Jacobsen, C. & Mikkelsen, J.D. Regional distribution of putative NPY Yl receptors in forebrain areas of the rat central nervous system. Eur. J. Neurosci. 5, 1622–1637 (1993).
Schaffhauser, A.O. et al. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes 46, 1792–1798 (1997).
Pedrazzini, T. et al. Cardiovascular response, feeding behaviour, and locomotor activity in mice lacking the NPY Yl receptor. Nature Med. 4, 722–726 (1998).
Marsh, D.J., Hollopeter, G., Kafer, K.E. & Palmiter, R.D. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nature Med. 4, 718–721 (1998).
Erickson, J.C., Clegg, K.E. & Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures in mice lacking neuropeptide Y. Nature 381, 415–118 (1996).
Broberger, C., Landry, M., Wong, H., Walsh, J.N. & Hökfelt, T. Subtypes of Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66, 393–408 (1997).
Erickson, J.C., Hollopeter, G. & Palmiter, R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274, 1704–1707 (1996).
Stephens, T.W. et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530–532 (1995).
Herzog, H. et al. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics 41, 315–319 (1997).
Wahlestedt, C. et al. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259, 528–531 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Woldbye, D., Larsen, P. The how and Y of eating. Nat Med 4, 671–672 (1998). https://doi.org/10.1038/nm0698-671
Issue Date:
DOI: https://doi.org/10.1038/nm0698-671