Despite exciting progress in the biology underlying a variety of proposed molecular medicines, an unmet challenge Remains—delivery. This problem, how to better target the new generation of therapeutics, cuts across all diseases. The solution offers unprecedented opportunities for multidisciplinary teams of bioengineers to work with biological and medical scientists to realize the fruits of our nation's investment in molecular and cellular medicine.
Access options
Subscribe to Journal
Get full journal access for 1 year
$225.00
only $18.75 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1
Jain, R.K. Delivery of Molecular Medicine to Solid Tumors. Science 271, 1079–1080 (1996).
- 2
Klausner, R.D., The Nation's Investment in Cancer Research: A Budget Proposal for Fiscal Year 1999. National Cancer Institute (September 1997).
- 3
Jain, R.K. 1996 Eugene M. Landis Award Lecture: Delivery of Molecular and Cellular Medicine to Solid Tumors. Microcirculation 4, 1–23 (1997).
- 4
Jain, R.K., Schlenger, K., Höckel, M. & Yuan, F. Quantitative Angiofenesis Assays: Progress and Problems. Nature Med. 3, 1203–1208 (1997).
- 5
Fidler, I.J. Modulation of the organ microenvironment for treatment of cancer metastasis. J. Natl. Cancer Inst. 87, 1588–1592 (1995).
- 6
Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 6, 353–64 (1996).
- 7
Kerbel, R.S. A cancer therapy resistant to resistance. Nature 390, 335–336 (1997).
- 8
Arap, W., Pasqualini, R. & Ruoslahti, E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279, 377–380 (1998).
- 9
Baxter, L.T., Zhu, H., Butler, W.F., Mackensen, D.G. & Jain, R.K. Biodistribution of monoclonal antibodies: scale-up from mouse to man using a physiologically-based pharmacokinetic model. Cancer Res. 55, 4611–4622 (1995).
Author information
Affiliations
Rights and permissions
About this article
Cite this article
Jain, R. The next frontier of molecular medicine: Delivery of therapeutics. Nat Med 4, 655–657 (1998) doi:10.1038/nm0698-655
Issue Date
DOI
Further reading
-
Oncolytic bacteria: past, present and future
FEMS Microbiology Letters (2019)
-
Targeted inactivation ofSalmonellaAgona metabolic genes by group II introns andin vivoassessment of pathogenicity and anti-tumour activity in mouse model
PeerJ (2019)
-
Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules
Journal of Nanobiotechnology (2019)
-
Nanomedicines for cancer therapy: current status, challenges and future prospects
Therapeutic Delivery (2019)
-
Active targeted delivery of immune therapeutics to lymph nodes
Current Opinion in Organ Transplantation (2018)