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Motors, channels and the sounds of silence

Mutations in myosin VIIA and connexin 26 lead to hereditary non-syndromic hearing loss

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References

  1. Kelsell, D.P. et al. Connexin 26 mutations in hereditary non-syndromic sensorineural deafness (DFNA3 and DFNB1). Nature 387, 80–83 (1997).

    Article  CAS  Google Scholar 

  2. Liu, X.-Z. et al. Mutations in the myosin VIIA gene cause non-syndromic recessive deafness. Nature Genet 16, 188–190 (1997).

    Article  CAS  Google Scholar 

  3. Weil, D. et al. The autosomal recessive isolated deafness, DFNB2, and the Usher 1B syndrome are allelic defects of the myosin VIIA gene. Nature Genet. 16, 191–193 (1997).

    Article  CAS  Google Scholar 

  4. Waelsch, S.G. Genetics of hearing impairment. NY Acad. Sci. 630, 3–5 (1991).

    Article  Google Scholar 

  5. Morton, N.E. Genetic epidemiology of hearing impairment. Ann. NY Acad. Sci. 630, 16–31 (1991).

    Article  CAS  Google Scholar 

  6. Gibson, F. et al. A type VII myosin encoded by the mouse deafness gene shaker-1. Nature 374, 62–64 (1995).

    Article  CAS  Google Scholar 

  7. Avraham, K.B. et al. The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for the structural integrity of inner ear hair cells. Nature Genet. 11, 369–375 (1995).

    Article  CAS  Google Scholar 

  8. Weil, D. et al. Defective myosin VIIA gene responsible for Usher syndrome type 1B. Nature 374, 60–61 (1995).

    Article  CAS  Google Scholar 

  9. Hasson, T. et al. Unconventional myosins in inner ear sensory epithelia. J. Cell Biol. (1997) in press.

  10. Kikuchi, T., Kimura, R.S., Paul, D.L. & Adams, J.C. Gap junctions in the rat cochlea: immuno-histochemical and ultrastructural analysis. Anat. Embryol. 191, 101–118 (1995).

  11. Solomon, A. Deaf is beautiful. N.Y. Times Magazine. August 28, section 6 (1994).

    Google Scholar 

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Avraham, K. Motors, channels and the sounds of silence. Nat Med 3, 608–609 (1997). https://doi.org/10.1038/nm0697-608

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