Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Second–generation adenovirus vectors

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Yang, N-S. Gene transfer into mammalian somatic cells in vivo. Critical Rev. Biotech. 12, 335–356 (1992).

    CAS  Article  Google Scholar 

  2. Kozarsdy, K.F., Wilson, J.M. Gene therapy: adenovirus vectors. Curr. Opin. Genet. Devel. 3, 499–503 (1993).

    Article  Google Scholar 

  3. Jones, N., Shenk, T. Isolation of adenovirus type 5 host range deletion mutants defective for transformation in rat embryo cells. Cell 17, 683–689 (1979).

    CAS  Article  Google Scholar 

  4. Reichel, R., Kovesdi, I., Nevins, M. Jr. Developmental control of a promoter-specific factor that is also regulated by the E1A gene product. Cell 48, 501–506 (1987).

    CAS  Article  Google Scholar 

  5. Zhang, Y., Schneider, RJ. Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cy-tokeratin network. j. Viral. 68, 2544–2555 (1994).

    CAS  Google Scholar 

  6. Valentine, R.C., Pereira, H.G. Antigens and structure of the adenovirus. j. Mol. Biol. 13, 13–20 (1965).

    CAS  Article  Google Scholar 

  7. Lochmuller, H.J. et al. Emergence of early region 1-containing replication-competent adenovirus in stocks of replication-defective adenovirus re-combinants (delta E1 + delta E3) during multiple passages in 293 cells. Hum. Gene Ther. 5, 1485–1491 (1994).

    CAS  Article  Google Scholar 

  8. Yang, Y. et al. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc. Not. Acad. Sci. USA 91, 4407–4411 (1994).

    CAS  Article  Google Scholar 

  9. Yang, Y., Ertl, H.C.J. & Wilson, J.M. MHC classl-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with El-deleted recombinant adenoviruses. Immunity 1, 433–442 (1994).

    CAS  Article  Google Scholar 

  10. Flint, J. & Broker, T.R. Lytic infections by adenoviruses in Molecular Biology of Tumor Viruses: DNA Tumor Viruses 2nd edn. (ed. Tooze, J.) 443–454 (Cold Spring Harbor Laboratory, 1980).

    Google Scholar 

  11. Engelhardt, J.F., Ye, X., Doranz, B. & Wilson, J.M. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196–6200 (1994).

    CAS  Article  Google Scholar 

  12. Golkman, M.J., Litzky, L.A., Engelhardt, J.F. & Wilson J.M. Transfer of the CFTR gene to the lung of nonhuman primates with El-deleted, E2a-defective recombinant adenoviruses: a pre-clinical toxicology study. Hum. Gene Ther. 6, 839–851 (1995).

    Article  Google Scholar 

  13. Horwitz, M.S. Adenovirudae and their replication in Virology 2nd edn (ed. Fields, B.N. et al.) 1679 1721 (Raven Press, New York, 1994).

    Google Scholar 

  14. Fang, B. et al. Lack of persistence of El-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in im-munocompetent mice and hemophilia B dogs. Gene Ther. 3, 217–222 (1996).

    CAS  PubMed  Google Scholar 

  15. Hrisse, J. & Rigolet, M., Dupont de Dinechin, S. & Gaubert, F. Nucleotide sequence of adenovirus 2 DNA fragment encoding for the car-boxylic region of the fiber protein and the entire E4 region. Nucleic Acid Res. 9, 4022–4042 (1981).

    Google Scholar 

  16. Sandier, A.B. & ketner, G. Adenovirus early region 4 is essential for normal stability of late nuclear RNAs. J. Virol. 63, 624–630 (1989).

    Google Scholar 

  17. Halbert, D.N., Cutt, J.R. & Shenk, T. Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J. Virol. 56, 250–257 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Weinberg, D.H. & Ketner, G. Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression. J. Virol. 57, 833–838 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Ketner, G., Bridge, E., Virtanen, A., Hemstrom, C. & Pettersson, U. Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids. Nucleic Acids Res. 17, 3037–3048 (1989).

    CAS  Article  Google Scholar 

  20. Babiss, L.E. & Ginsberg, H.S. Adenovirus type 5 early region Ib gene product is required for efficient shutoff of host protein synthesis. J. Virol. 50, 202–212 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Bridge, E., St Ketner, G. Interaction of adenoviral E4 and Elb products in late gene expression. Virology 174, 345–353 (1990).

    CAS  Article  Google Scholar 

  22. Wang, Q. & Taylor, M.W. Correction of deletion mutant using adenovirus vector. Mol. Cell. Biol. 13, 918–927 (1993).

    CAS  Article  Google Scholar 

  23. Ayumi, F., Keiko, S., Yumi, D., Izumu, S. & Ichizo, K. Gene targeting with a replication-defective adenovirus vector. J. Virol. 69, 6180–6190 (1995).

    Google Scholar 

  24. Klessig, K.F., Brough, K.E. & Cleghon, V. Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell. Mol. Cell Biol. 4, 1354–1362 (1984).

    CAS  Article  Google Scholar 

  25. Nevins, J.R. Regulation of early adenovirus gene expression. Microbiol Rev. 51, 419–430 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Su, J.J. & Hsueh, A.J.W. Characterization of mouse inhibin a gene and its promoter. Biochem. Biophys. Res, Commun. 186, 293–300 (1992).

    CAS  Article  Google Scholar 

  27. Wang, Q., Jia, X.-C. & Finer, M.H. A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions. Gene Ther. 2, 775–783 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Kim, K.-S., Lee, M.K., Carroll, J. & Hob, T.H. Both the basal and inducible transcription of the tyrosine hydroxylase gene are dependent upon a cAMP response element. J. Biol. Chem. 268, 15689–15695 (1993).

    CAS  PubMed  Google Scholar 

  29. Couture, L.A. et al. The use of alternative vectors for gene transfer to lung epithelia and tissue culture cells. Pedlatr. Pulm. Suppl. 8, 237 (1992).

    Google Scholar 

  30. Norrby, E. The relationship between soluble antigens and the virion of adenovirus type 3. 1. Morphological characteristics. Virology 28, 236–248 (1966).

    CAS  Google Scholar 

  31. Philipson, L., Pettersson, U. & Lindberg, U. Virus-receptor interaction in an adenovirus system. J. Virol. 2, 1064–1075 (1975).

    Google Scholar 

  32. Hierholzer, J.C. Further subgrouping of the human adenoviruses by differential hemaggluti-nation. J. Infect. Dis. 128, 541–550 (1973).

    CAS  Article  Google Scholar 

  33. Dong, J.-Y., Wang, D., Van Ginkel, F.W., Pascual, D.W. & Frizzell, R.A. Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector. Hum. Gene Ther. 7, 319–331 (1996).

    CAS  Article  Google Scholar 

  34. Van Ginkel, F.W. et al. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and |3-galactosidase. Hum. Gene Ther. 6, 895–903 (1995).

    CAS  Article  Google Scholar 

  35. Kass-Eisler, A., Leinwand, L., Gall, J., Bloom, B. & Falck-Pedersen, E. Circumventing the immune response to adenovirus-mediated gene therapy. Gene Ther. 3, 154–162 (1996).

    CAS  PubMed  Google Scholar 

  36. Yang, Y., Trinchieri, G. & Wilson, J.M. Recombinant IL-2 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1, 890–893 (1995).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wang, Q., Finer, M. Second–generation adenovirus vectors. Nat Med 2, 714–716 (1996). https://doi.org/10.1038/nm0696-714

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0696-714

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing