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ERasing breast cancer resistance through the kinome

Estrogen receptor α (ERα)-positive breast cancers often find a way to circumvent endocrine therapies such as tamoxifen. A newly described ERα kinase, lemur tyrosine kinase-3 (LMTK3), may provide both a diagnostic advance and a new therapeutic target to fight these resistant, aggressive tumors.

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Figure 1: LMTK3 positively regulates ESR1 gene transcription, protein levels and phosphorylation, promoting resistance to endocrine therapies.

Marina Corral


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Correspondence to Bert W O'Malley.

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Johnson, A., O'Malley, B. ERasing breast cancer resistance through the kinome. Nat Med 17, 660–661 (2011).

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