Estrogen receptor α (ERα)-positive breast cancers often find a way to circumvent endocrine therapies such as tamoxifen. A newly described ERα kinase, lemur tyrosine kinase-3 (LMTK3), may provide both a diagnostic advance and a new therapeutic target to fight these resistant, aggressive tumors.
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References
Orlando, L. et al. Cancer Treat. Rev. 36 Suppl 3, S67–S71 (2010).
Ali, S. & Coombes, R.C. Nat. Rev. Cancer 2, 101–112 (2002).
Romano, A. et al. Mol. Cell. Endocrinol. 314, 90–100 (2010).
Osborne, C.K. et al. J. Natl. Cancer Inst. 95, 353–361 (2003).
Jordan, V.C. & O'Malley, B.W. J. Clin. Oncol. 25, 5815–5824 (2007).
Lonard, D.M., Tsai, S.Y. & O'Malley, B.W. Mol. Cell. Biol. 24, 14–24 (2004).
Zwart, W. et al. EMBO J. 26, 3534–3544 (2007).
Kato, S. et al. Science 270, 1491–1494 (1995).
Sarwar, N. et al. Endocr. Relat. Cancer 13, 851–861 (2006).
Giamas, G. et al. Nat. Med. 17, 715–719 (2011).
Guo, S. & Sonenshein, G.E. Mol. Cell. Biol. 24, 8681–8690 (2004).
Belguise, K. & Sonenshein, G.E. J. Clin. Invest. 117, 4009–4021 (2007).
Marsaud, V., Gougelet, A., Maillard, S. & Renoir, J.M. Mol. Endocrinol. 17, 2013–2027 (2003).
Xu, J., Wu, R.C. & O'Malley, B.W. Nat. Rev. Cancer 9, 615–630 (2009).
Hudis,, C.A. N. Engl. J. Med. 357, 39–51 (2007).
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Johnson, A., O'Malley, B. ERasing breast cancer resistance through the kinome. Nat Med 17, 660–661 (2011). https://doi.org/10.1038/nm0611-660
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DOI: https://doi.org/10.1038/nm0611-660
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