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A CUE hints at tumor resistance

Some individuals with estrogen receptor–α (ER-α)-positive breast cancer do not respond to tamoxifen treatment. Increased expression of the ubiquitin ligase CUEDC2 may contribute to this endocrine resistance by reducing theamounts of ER-α (pages 708–714).

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Figure 1: CUEDC2 and ER-α expression in tamoxifen-resistant tumor cells.

Renee Lucas


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Correspondence to Jan-Ake Gustafsson.

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Thomas, C., Gustafsson, JA. A CUE hints at tumor resistance. Nat Med 17, 658–660 (2011).

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