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The holy grail of high bone mass

Humans with a missense mutation in LRP5 (encoding lipoprotein receptor-related protein 5) have a high bone mass phenotype, which has now been recapitulated in mice conditionally expressing this Lrp5 variant in terminally differentiated bone osteocytes (pages 684–691). These results suggest that LRP5 acts locally to increase bone mass, thereby opening avenues for new therapeutics for osteoporosis and bone injury by manipulating LRP5 signaling.

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Figure 1: Osteoblasts are descended from mesenchymal stem cells.

Katie Vicari


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Correspondence to Lynda Bonewald.

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Bonewald, L. The holy grail of high bone mass. Nat Med 17, 657–658 (2011).

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