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Heat shock and awe

New drugs that neutralize so-called 'heat shock' proteins are nearing market approval to treat cancer. Yet, beyond their tumor-fighting potential, these same drugs have also shown promise against parasites, inflammatory diseases and even neurodegenerative disorders. Elie Dolgin and Alison Motluk talk with the scientists hoping these drugs will turn up the temperature on a broad range of disease targets.

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References

  1. Banumathy, G., Singh, V., Pavithra, S.R. & Tatu, U. J. Biol. Chem. 278, 18336–18345 (2003).

    Article  CAS  Google Scholar 

  2. Kumar, R., Pavithra, S.R. & Tatu, U. J. Biosci. 32, 531–536 (2007).

    Article  Google Scholar 

  3. Pallavi, R. et al. J. Biol. Chem. 285, 37964–37975 (2010).

    Article  CAS  Google Scholar 

  4. Geller, R., Vignuzzi, M., Andino, R. & Frydman, J. Genes Dev. 21, 195–205 (2007).

    Article  CAS  Google Scholar 

  5. Cowen, L.E. & Lindquist, S. Science 309, 2185–2189 (2005).

    Article  CAS  Google Scholar 

  6. Cowen, L.E. et al. Proc. Natl. Acad. Sci. USA 106, 2818–2823 (2009).

    Article  CAS  Google Scholar 

  7. Devaney, E., O'Neill, K., Harnett, W., Whitesell, L. & Kinnaird, J.H. Int. J. Parasitol. 35, 627–636 (2005).

    Article  CAS  Google Scholar 

  8. Taldone, T. et al. PLoS Negl. Trop. Dis. 4, e714 (2010).

    Article  Google Scholar 

  9. Shahinas, D., Liang, M., Datti, A. & Pillai, D.R. J. Med. Chem. 53, 3552–3557 (2010).

    Article  CAS  Google Scholar 

  10. Dello Russo, C. et al. J. Neurochem. 99, 1351–1362 (2006).

    Article  Google Scholar 

  11. Yun, T.J. et al. J. Immunol. 186, 563–575 (2011).

    Article  CAS  Google Scholar 

Download references

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Dolgin, E., Motluk, A. Heat shock and awe. Nat Med 17, 646–649 (2011). https://doi.org/10.1038/nm0611-646

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