Multiple layers of metabolism

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A new layer of gene regulation emerges for the metabolic regulator peroxisome proliferator–activated receptor-δ (PPAR-δ). A team consisting of a Krüppel-like transcription factor and a SUMO protease regulate the expression of PPAR-δ target genes, thereby controlling energy metabolism (pages 656–666).

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Figure 1: Modulation of nuclear receptor transcriptional activity by SUMOylation.

Kim Caesar

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