A new layer of gene regulation emerges for the metabolic regulator peroxisome proliferator–activated receptor-δ (PPAR-δ). A team consisting of a Krüppel-like transcription factor and a SUMO protease regulate the expression of PPAR-δ target genes, thereby controlling energy metabolism (pages 656–666).
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Jain, M. Multiple layers of metabolism. Nat Med 14, 603–604 (2008). https://doi.org/10.1038/nm0608-603
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DOI: https://doi.org/10.1038/nm0608-603
