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The hydrogen highway to reperfusion therapy

Nature Medicine volume 13, pages 673–674 (2007)Cite this article

Hydrogen gas debuts as a selective antioxidant with explosive potential as cytoprotective therapy for ischemia-reperfusion injury and stroke.

Just when we thought we had exhausted our tool kit of therapeutic gases, Ohsawa et al.1 provide evidence that inhaled hydrogen gas (H2) has antioxidant and antiapoptotic activities that protect the brain against ischemia-reperfusion injury and stroke1.

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Figure 1: Dihydrogen (H2) scavenging of mitochondrial reactive oxygen species.

Kim Caesar

References

  1. Ohsawa, I. et al. Nat. Med. 13, 688–694 (2007).

    CAS  Article  Google Scholar 

  2. Garlick, P.B., Davies, M.J., Hearse, D.J. & Slater, T.F. Circ. Res. 61, 757–760 (1987).

    CAS  Article  Google Scholar 

  3. Kim, J.S., Jin, Y. & Lemasters, J.J. Am. J. Physiol. Heart Circ. Physiol. 290, H2024–H2034 (2006).

    CAS  Article  Google Scholar 

  4. Zweier, J.L., Flaherty, J.T. & Weisfeldt, M.L. Proc. Natl. Acad. Sci. USA 84, 1404–1407 (1987).

    CAS  Article  Google Scholar 

  5. Chen, Q., Moghaddas, S., Hoppel, C.L. & Lesnefsky, E.J. J. Pharmacol. Exp. Ther. 319, 1405–1412 (2006).

    CAS  Article  Google Scholar 

  6. Burwell, L.S., Nadtochiy, S.M., Tompkins, A.J., Young, S. & Brookes, P.S. Biochem. J. 394, 627–634 (2006).

    CAS  Article  Google Scholar 

  7. Gladwin, M.T. et al. Nat. Chem. Biol. 1, 308–314 (2005).

    CAS  Article  Google Scholar 

  8. Labiche, L.A. & Grotta, J.C. NeuroRx 1, 46–70 (2004).

    Article  Google Scholar 

  9. Bolli, R. Basic Res. Cardiol. 93, 156–162 (1998).

    CAS  Article  Google Scholar 

  10. Buxton, G.V., Greenstock, C.L., Helman, W.P. & Ross, A.B. J. Phys. Chem. Ref. Data 17, 513–886 (1988).

    CAS  Article  Google Scholar 

  11. Bolli, R. et al. Circ. Res. 95, 125–134 (2004).

    CAS  Article  Google Scholar 

  12. Sheu, S.S., Nauduri, D. & Anders, M.W. Biochim. Biophys. Acta 1762, 256–265 (2006).

    CAS  Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Intramural Research Division, Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Katherine C Wood & Mark T Gladwin

Authors
  1. Katherine C Wood
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  2. Mark T Gladwin
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The authors declare no competing financial interests.

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Wood, K., Gladwin, M. The hydrogen highway to reperfusion therapy. Nat Med 13, 673–674 (2007). https://doi.org/10.1038/nm0607-673

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