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The hydrogen highway to reperfusion therapy

Hydrogen gas debuts as a selective antioxidant with explosive potential as cytoprotective therapy for ischemia-reperfusion injury and stroke.

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Figure 1: Dihydrogen (H2) scavenging of mitochondrial reactive oxygen species.

Kim Caesar

References

  1. Ohsawa, I. et al. Nat. Med. 13, 688–694 (2007).

    CAS  Article  Google Scholar 

  2. Garlick, P.B., Davies, M.J., Hearse, D.J. & Slater, T.F. Circ. Res. 61, 757–760 (1987).

    CAS  Article  Google Scholar 

  3. Kim, J.S., Jin, Y. & Lemasters, J.J. Am. J. Physiol. Heart Circ. Physiol. 290, H2024–H2034 (2006).

    CAS  Article  Google Scholar 

  4. Zweier, J.L., Flaherty, J.T. & Weisfeldt, M.L. Proc. Natl. Acad. Sci. USA 84, 1404–1407 (1987).

    CAS  Article  Google Scholar 

  5. Chen, Q., Moghaddas, S., Hoppel, C.L. & Lesnefsky, E.J. J. Pharmacol. Exp. Ther. 319, 1405–1412 (2006).

    CAS  Article  Google Scholar 

  6. Burwell, L.S., Nadtochiy, S.M., Tompkins, A.J., Young, S. & Brookes, P.S. Biochem. J. 394, 627–634 (2006).

    CAS  Article  Google Scholar 

  7. Gladwin, M.T. et al. Nat. Chem. Biol. 1, 308–314 (2005).

    CAS  Article  Google Scholar 

  8. Labiche, L.A. & Grotta, J.C. NeuroRx 1, 46–70 (2004).

    Article  Google Scholar 

  9. Bolli, R. Basic Res. Cardiol. 93, 156–162 (1998).

    CAS  Article  Google Scholar 

  10. Buxton, G.V., Greenstock, C.L., Helman, W.P. & Ross, A.B. J. Phys. Chem. Ref. Data 17, 513–886 (1988).

    CAS  Article  Google Scholar 

  11. Bolli, R. et al. Circ. Res. 95, 125–134 (2004).

    CAS  Article  Google Scholar 

  12. Sheu, S.S., Nauduri, D. & Anders, M.W. Biochim. Biophys. Acta 1762, 256–265 (2006).

    CAS  Article  Google Scholar 

Download references

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Wood, K., Gladwin, M. The hydrogen highway to reperfusion therapy. Nat Med 13, 673–674 (2007). https://doi.org/10.1038/nm0607-673

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