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Linking calcineurin activity to leukemogenesis

Nature Medicine volume 13, pages 669–671 (2007)Cite this article

Aberrant activation of the protein phosphatase calcineurin is found in various cancer types. Inhibition of calcineurin leads to a rapid clearance of leukemic cells and significantly improves animal survival in two mouse models of acute T lymphoblastic leukemia.

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Figure 1: Potential role of the calcineurin-NFAT pathway in the pathogenesis of cancer.

Kim Caesar

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Authors and Affiliations

  1. Department of Pathology, Harvard Medical School and the CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, 02115, Massachusetts, USA

    Martin R Müller & Anjana Rao

Authors
  1. Martin R Müller
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  2. Anjana Rao
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Competing interests

A.R. is scientific founder of a company, Calcimedica, that seeks to identify novel treatments for immune-related diseases.

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Müller, M., Rao, A. Linking calcineurin activity to leukemogenesis. Nat Med 13, 669–671 (2007). https://doi.org/10.1038/nm0607-669

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