In a mouse model of cerebral malaria, free heme molecules can induce inflammation and permeabilization of the blood brain barrier, leading to death. The enzyme heme oxygenase-1 or its product carbon monoxide can decrease free heme levels, offering a new therapeutic approach to this deadly complication.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Pamplona, A. et al. Nat. Med. 13, 703–710 (2007).
Hunt, N.H. & Grau, G.E. Trends Immunol. 24, 491–499 (2003).
Belnoue, E. et al. J. Immunol. 169, 6369–6375 (2002).
Gramaglia, I. et al. Nat. Med. 12, 1417–1422 (2006).
Kossodo, S. et al. Immunology 91, 536–540 (1997).
Stocker, R. & Perrella, M.A. Circulation 114, 2178–2189 (2006).
Abraham, N.G. et al. Proc. Natl. Acad. Sci. USA 92, 6798–6802 (1995).
Clark, I.A., Awburn, M.M., Harper, C.G., Liomba, N.G. & Molyneux, M.E. Malar. J. [online] 2, 41 (2003).
Hvidberg, V. et al. Blood 106, 2572–2579 (2005).
Cunnington, A.J., Kendrick, S.F., Wamola, B., Lowe, B. & Newton, C.R. Am. J. Trop. Med. Hyg. 71, 43–47 (2004).
Takeda, M. et al. Jpn. J. Infect. Dis. 58, 268–271 (2005).
Gordeuk, V.R. et al. Blood 85, 3297–3301 (1995).
Koury, M.J. & Ponka, P. Annu. Rev. Nutr. 24, 105–131 (2004).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
Personal financial interest in form of consultancy fee, and the possibility of future research support. The authors declare that they are bound by confidentiality agreements that prevent them from further disclosing their financial interests in this work.
Rights and permissions
About this article
Cite this article
Hunt, N., Stocker, R. Heme moves to center stage in cerebral malaria. Nat Med 13, 667–669 (2007). https://doi.org/10.1038/nm0607-667
Issue Date:
DOI: https://doi.org/10.1038/nm0607-667
This article is cited by
-
A pulse radiolysis study of free radicals formed by one-electron oxidation of the antimalarial drug pyronaridine
Research on Chemical Intermediates (2009)