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T cells take the inside track

Being in constant contact with the environment, the lung has evolved special mechanisms for resisting infections such as influenza. A newly discovered mechanism assures that influenza-specific T cells do not enter the general circulation. Instead, they recirculate between the draining lymph node and the respiratory mucosa—so remaining close to the site of infection.

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Figure 1: T cells caught in the loop.

Katie Ris

References

  1. Mizgerd, J.P. PLoS Med. 3, e76 (2006).

    Article  Google Scholar 

  2. Zammit, D.J., Turner, D.L., Klonowski, K.D., Lefrancois, L. & Cauley, L.S. Immunity 24, 439–449 (2006).

    Article  CAS  Google Scholar 

  3. Vermaelen, K.Y., Carro-Muino, I., Lambrecht, B.N. & Pauwels, R.A. J. Exp. Med. 193, 51–60 (2001).

    Article  CAS  Google Scholar 

  4. Kohlmeier, J.E. & Woodland, D.L. Curr. Opin. Immunol. 18, 357–362 (2006).

    Article  CAS  Google Scholar 

  5. Lawrence, C.W. & Braciale, T.J. J. Immunol. 173, 1209–1218 (2004).

    Article  CAS  Google Scholar 

  6. Cannon, M.J., Openshaw, P.J.M. & Askonas, B.A. J. Exp. Med. 168, 1163–1168 (1988).

    Article  CAS  Google Scholar 

  7. Julia, V. et al. Immunity 16, 271–283 (2002).

    Article  CAS  Google Scholar 

  8. Klenerman, P., Hengartner, H. & Zinkernagel, R.M. Nature 390, 298–301 (1997).

    Article  CAS  Google Scholar 

  9. Sykulev, Y., Joo, M., Vturina, I., Tsomides, T.J. & Eisen, H.N. Immunity 4, 565–571 (1996).

    Article  CAS  Google Scholar 

  10. Chen, H.D. et al. Nat. Immunol. 2, 1067–1076 (2001).

    Article  CAS  Google Scholar 

Download references

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Openshaw, P. T cells take the inside track. Nat Med 12, 614–615 (2006). https://doi.org/10.1038/nm0606-614

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  • DOI: https://doi.org/10.1038/nm0606-614

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