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T cells take the inside track

Being in constant contact with the environment, the lung has evolved special mechanisms for resisting infections such as influenza. A newly discovered mechanism assures that influenza-specific T cells do not enter the general circulation. Instead, they recirculate between the draining lymph node and the respiratory mucosa—so remaining close to the site of infection.

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Figure 1: T cells caught in the loop.

Katie Ris


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Openshaw, P. T cells take the inside track. Nat Med 12, 614–615 (2006).

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