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Bone loss goes beyond estrogen

Nature Medicine volume 12, pages 612–613 (2006)Cite this article

The central position of estrogen in the physiological and pharmacological control of bone resorption is now challenged by evidence from mouse genetics of estrogen-independent control by pituitary FSH.

Since Fuller Albright suggested that osteoporosis was due to hormone deficiency at the menopause1, simple sex-steroid deficiency has been considered the cause of bone loss. This has underpinned many approaches to prevention and treatment.

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Figure 1: The potential effects of FSH on the skeleton in vivo, either directly upon bone or indirectly.

Katie Ris

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Authors and Affiliations

  1. St. Vincent's Institute of Medical Research, Victoria, 3065, Fitzroy, Australia

    T John Martin

  2. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, 72205, Arkansas, USA

    Dana Gaddy

Authors
  1. T John Martin
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  2. Dana Gaddy
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Martin, T., Gaddy, D. Bone loss goes beyond estrogen. Nat Med 12, 612–613 (2006). https://doi.org/10.1038/nm0606-612

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  • DOI: https://doi.org/10.1038/nm0606-612

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