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Bone loss goes beyond estrogen

The central position of estrogen in the physiological and pharmacological control of bone resorption is now challenged by evidence from mouse genetics of estrogen-independent control by pituitary FSH.

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Figure 1: The potential effects of FSH on the skeleton in vivo, either directly upon bone or indirectly.

Katie Ris

References

  1. Albright, F. Smith, P.H. & Richardson, A.M. JAMA 116, 2465–2474 (1941).

    Article  Google Scholar 

  2. Sun, L. et al. Cell 125, 247–260 (2006).

    Article  CAS  Google Scholar 

  3. Danilovich, N. et al. Endocrinology 141, 4295–4308 (2000).

    Article  CAS  Google Scholar 

  4. Manolagas, S.C. & Jilka, R.L. N. Engl. J. Med. 332, 305–311 (1995).

    Article  CAS  Google Scholar 

  5. Eghbali-Fatourechi, G. et al. J. Clin. Invest. 111, 1221–1230 (2003).

    Article  CAS  Google Scholar 

  6. Burger, H.G. et al. Recent Prog. Horm. Res. 57, 257–275 (2002).

    Article  CAS  Google Scholar 

  7. Welt, C.K. et al. J. Clin. Endocrinol. Metab. 84, 105–111 (1999).

    CAS  PubMed  Google Scholar 

  8. Gaddy-Kurten, D. et al. Endocrinology 143,74–83 (2002).

    Article  CAS  Google Scholar 

  9. Perrien, D.S. et al. J. Clin. Endocrinol. Metab. 91, 1848–1854 (2006).

    Article  CAS  Google Scholar 

  10. Ebeling, P.R. J. Clin. Endocrinol. Metab. 91, 1669–1670 (2006).

    Article  CAS  Google Scholar 

  11. Vural, F. et al. Maturitas 52, 147–153 (2005).

    Article  CAS  Google Scholar 

Download references

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Martin, T., Gaddy, D. Bone loss goes beyond estrogen. Nat Med 12, 612–613 (2006). https://doi.org/10.1038/nm0606-612

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