Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Bone loss goes beyond estrogen

The central position of estrogen in the physiological and pharmacological control of bone resorption is now challenged by evidence from mouse genetics of estrogen-independent control by pituitary FSH.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The potential effects of FSH on the skeleton in vivo, either directly upon bone or indirectly.

Katie Ris


  1. Albright, F. Smith, P.H. & Richardson, A.M. JAMA 116, 2465–2474 (1941).

    Article  Google Scholar 

  2. Sun, L. et al. Cell 125, 247–260 (2006).

    Article  CAS  Google Scholar 

  3. Danilovich, N. et al. Endocrinology 141, 4295–4308 (2000).

    Article  CAS  Google Scholar 

  4. Manolagas, S.C. & Jilka, R.L. N. Engl. J. Med. 332, 305–311 (1995).

    Article  CAS  Google Scholar 

  5. Eghbali-Fatourechi, G. et al. J. Clin. Invest. 111, 1221–1230 (2003).

    Article  CAS  Google Scholar 

  6. Burger, H.G. et al. Recent Prog. Horm. Res. 57, 257–275 (2002).

    Article  CAS  Google Scholar 

  7. Welt, C.K. et al. J. Clin. Endocrinol. Metab. 84, 105–111 (1999).

    CAS  PubMed  Google Scholar 

  8. Gaddy-Kurten, D. et al. Endocrinology 143,74–83 (2002).

    Article  CAS  Google Scholar 

  9. Perrien, D.S. et al. J. Clin. Endocrinol. Metab. 91, 1848–1854 (2006).

    Article  CAS  Google Scholar 

  10. Ebeling, P.R. J. Clin. Endocrinol. Metab. 91, 1669–1670 (2006).

    Article  CAS  Google Scholar 

  11. Vural, F. et al. Maturitas 52, 147–153 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Martin, T., Gaddy, D. Bone loss goes beyond estrogen. Nat Med 12, 612–613 (2006).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing