Osteoclasts carve out the marrow space where hematopoietic stem cells reside, but they have been considered bystanders during hematopoiesis. Osteoclasts are now shown to mediate stem cell mobilization, enabling stem cell emigration from the marrow to the circulation (pages 657 – 664).
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Purton, L., Scadden, D. Osteoclasts eat stem cells out of house and home. Nat Med 12, 610–611 (2006). https://doi.org/10.1038/nm0606-610
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DOI: https://doi.org/10.1038/nm0606-610
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