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Defending the epithelium

Two studies examine the microbe-fighting peptides that keep infection at bay in the urinary tract and the colon. In the urinary tract, such peptides are deployed with lightning speed, and in the colon a short-chain fatty acid induces the peptides and fends off dysentery caused by Shigella species (pages 636 – 641).

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Figure 1: Cathelicidins defend the kidney from bacteria.

Katie Ris


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Zasloff, M. Defending the epithelium. Nat Med 12, 607–608 (2006).

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