Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gateway to the metabolic syndrome

A high-fat diet can lead to insulin resistance and the development of the metabolic syndrome, a condition associated with diabetes, heart disease and other ailments. A G-protein-coupled receptor on the surface of insulin-secreting cells in the pancreas senses lipids and may promote the metabolic syndrome under high-fat conditions.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: GPR40 mediates acute and chronic effects of fatty acids on insulin secretion.

Katie Ris


  1. Moller, D.E. & Kaufman, K.D. Annu. Rev. Med. 56, 45–62 (2005).

    Article  CAS  Google Scholar 

  2. Steneberg, P., Rubins, N., Bartoov-Shifman, R., Walker, M. & Edlund, H. Cell Metabolism 1, 245–258 (2005).

    Article  CAS  Google Scholar 

  3. Lelliott, C. & Vidal-Puig, A.J. Int. J. Obes. Relat. Metab. Disord. 28 Suppl 4, S22–S28 (2004).

    Article  CAS  Google Scholar 

  4. Unger, R.H. Annu. Rev. Physiol. 65, 333–347 (2003).

    Article  CAS  Google Scholar 

  5. Itoh, Y. et al. Nature 422, 173–176 (2003).

    Article  CAS  Google Scholar 

  6. Briscoe, C.P. et al. J. Biol. Chem. 278, 11303–11311 (2003).

    Article  CAS  Google Scholar 

  7. Echtay, K.S. et al. Nature 415, 96–99 (2002).

    Article  CAS  Google Scholar 

  8. Krauss, S., Zhang, C.Y. & Lowell, B.B. Nat. Rev. Mol. Cell Biol. 6, 248–261 (2005).

    Article  CAS  Google Scholar 

  9. Tordjman, K. et al. J. Lipid Res. 43, 936–943 (2002).

    CAS  PubMed  Google Scholar 

  10. Zhang, C.Y. et al. Cell 105, 745–755 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Medina-Gomez, G., Vidal-Puig, A. Gateway to the metabolic syndrome. Nat Med 11, 602–603 (2005).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing