The theory that oxidative stress limits lifespan and causes age-related disease rests on experiments in invertebrates and correlative evidence from studies in mammals. This theory now gains a strong experimental basis in mammals.
This is a preview of subscription content
Access options
Subscribe to Journal
Get full journal access for 1 year
$59.00
only $4.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.

Katie Ris
References
Schriner, S.E. et al. Science, Published online 5 May 2005 (10.1126/science.1106653).
Wang, Y. et al. Proc. Natl. Acad. Sci. USA 98, 4022–4027 (2001).
Zhang, J. et al. Proc. Natl. Acad. Sci. USA 100, 1116–1121 (2003).
Wang, J., Xiong, S., Xie, C., Markesbery, W.R. & Lovell, M.A. J. Neurochem. 93, 953–962 (2005).
Mecocci, P. et al. Ann. Neurol. 34, 609–616 (1993).
Lin, M.T., Simon, D.K., Ahn, C.H., Kim, L.M. & Beal, M.F. Hum. Mol. Genet. 11, 133–145 (2002).
Trifunovic, A. et al. Nature 429, 417–423 (2004).
Lu, T. et al. Nature 429, 883–891 (2004).
Ruan, H. et al. Proc. Natl. Acad. Sci. USA 99, 2748–2753 (2002).
Moskovitz, J. et al. Proc. Natl. Acad. Sci. USA 98, 12920–12925 (2001).
Mitsui, A. et al. Antioxid. Redox Signal. 4, 693–696 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Beal, M. Less stress, longer life. Nat Med 11, 598–599 (2005). https://doi.org/10.1038/nm0605-598
Issue Date:
DOI: https://doi.org/10.1038/nm0605-598
Further reading
-
Real-Time Monitoring of Oxidative Stress in Live Mouse Skin
Journal of Investigative Dermatology (2014)
-
Boolean modeling and fault diagnosis in oxidative stress response
BMC Genomics (2012)