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The biology of VEGF and its receptors

Abstract

Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF RTK signaling. Currently, several VEGF inhibitors are undergoing clinical testing in several malignancies. VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration.

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Figure 1: The VEGF isoforms and their interaction with VEGF receptors.

Debbie Maizels

Figure 2: Role of the VEGF receptor tyrosine kinases in different cell types.

Debbie Maizels

Figure 3: Differential effects of VEGFR-1 (R1) and VEGFR-2 (R2) in LSECs.

Debbie Maizels

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Correspondence to Napoleone Ferrara.

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Ferrara, N., Gerber, HP. & LeCouter, J. The biology of VEGF and its receptors. Nat Med 9, 669–676 (2003). https://doi.org/10.1038/nm0603-669

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