Each year a new flu vaccine is produced, and judging which strains to target is a tricky business. A new study evaluating viral evolution suggests a more systematic approach to predicting next year's virus.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The prediction of virus mutation using neural networks and rough set techniques
EURASIP Journal on Bioinformatics and Systems Biology Open Access 13 May 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Glezen, W.P. Emerging infections: pandemic influenza. Epidemiol Rev. 18, 64–76 (1996).
Fitch, W.M., Leiter, J.M., Li, X.Q. & Palese, P., Positive Darwinian evolution in human influenza A viruses. Proc. Natl. Acad. Sci. USA 88, 4270–4270 (1991).
Bush, R.M., Bender, C.A., Subbarao, K., Cox, N.J. & Fitch, W.M. Predicting the evolution of human influenza A. Science 286, 1921–1925 (1999).
Plotkin, J.B., Dushoff, J. & Levin, S.A. Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus. Proc. Natl. Acad. Sci. USA 99, 6263–6268 (2002).
Bush, R.M., Smith, C.B., Cox, N.J. & Fitch, W.M. Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution. Proc. Natl. Acad. Sci. USA 97, 6974–6980 (2000).
Gordon, A.D. Classification. (Chapman & Hall/CRC, London, 1999).
Everitt, B.S., Landau, S. & Leese, M. Cluster Analysis. (Edward Arnold, London, 2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ferguson, N., Anderson, R. Predicting evolutionary change in the influenza A virus. Nat Med 8, 562–563 (2002). https://doi.org/10.1038/nm0602-562
Issue Date:
DOI: https://doi.org/10.1038/nm0602-562
This article is cited by
-
The prediction of virus mutation using neural networks and rough set techniques
EURASIP Journal on Bioinformatics and Systems Biology (2016)
-
Predicting the Emergence of H3N2 Influenza Viruses Reveals Contrasted Modes of Evolution of HA and NA Antigens
Journal of Molecular Evolution (2014)