Inconclusive results from linkage studies of bipolar illness mirror the complexity of the disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Poe, E.A. The Fall of the House of Usher and Other Writings (1839; reprint, Penguin Books, London, 1986).
Goodwin, F.K. & Jamison, K.R. Manic-Depressive Illness. (Oxford University Press, New York, 1990).
Regier, D.A. et al. One-month prevalence of mental disorders in the United States: Based on five epidemiological catchment areas. Arch. Gen. Psychiatry 44, 977–986 (1988).
Kessler, R.C. et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the national comorbidity survey. Arch. Gen. Psychiatry 51, 8–19 (1994).
Angst, J. The course of major depression, atypical bipolar disorder, and bipolar disorder. in New Results in Depression Research, (eds. Hippius, H., Klerman, G.L. & Matussek, N.) (Springer-Verlag, Berlin, 1986).
Roy-Byrne, P., Post, R.M., Uhde, T.W., Porcu, T. & Davis, D. The longitudinal course of recurrent affective illness: Life chart data from research patients at the NIMH. Ada Psychiatr. Scand. 71 (suppl. 317), 1–34 (1985).
Regier, D.A. et al. Co-morbidity of mental disorders with drug and alcohol abuse: Results from the Epidemiologic Catchment Area (EGA) study. JAMA 264, 2511–2518 (1990).
Wyatt, R.L. & Henter, I. An economic evaluation of manic-depressive illness — 1991. Soc. Psychiatry Psychiatr. Epidemiol. 30, 213–219 (1995).
Blackwood, D.H.R. et al. A locus for bipolar affective disorder on chromosome 4p. Nature Genet. 12, 427–430 (1996).
Ginns, E.I. A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nature Genet. 12, 431–435 (1996).
Freimer, N.B. et al. Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22–q23. Nature Genet. 12, 436–441 (1996).
Berrettini, W. et al. Chromosome 18 DNA markers and manic-depressive illness: Evidence for a susceptibility gene. Proc. Natl. Acad. Sci. USA 91, 5918–5921 (1994).
Stine, O.C. et al. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am. J. Hum. Genet. 57, 1384–1394 (1995).
Richards, R.L. Relationships between creativity and psychopathology: An evaluation and interpretation of the evidence. Genet. Psychol. Monogr. 103, 261–324 (1981).
Jamison, K.R. Touched With Fire: Manic-Depressive Illness and the Artistic Temperament. (Free Press, New York, 1993).
Baxter, L.R. et al. Cerebral metabolic rates in mood disorders: Studies with positron emission tomography and fluorodeoxyglucose F18. Arch. Gen. Psychiatry 42, 441–447 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jamison, K., McInnis, M. Genetic studies of manic–depressive illness. Nat Med 2, 521–522 (1996). https://doi.org/10.1038/nm0596-521
Issue Date:
DOI: https://doi.org/10.1038/nm0596-521