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Mitochondrial toxicity of antiviral drugs


Long-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest in many tissues, a common disease mechanism can explain the diverse clinical events. A better understanding of these disorders will shed light on genetic mitochondrial diseases and lead to the design of safer and more effective antiviral drugs.

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Lewis, W., Dalakas, M. Mitochondrial toxicity of antiviral drugs. Nat Med 1, 417–422 (1995).

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