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Shedding LIGHT on severe asthma

Moderate to severe asthma is difficult to treat because recurring bouts of inflammation in the lungs induce fibrosis, which reduces lung elasticity, gas exchange and responses to conventional therapy. A recent study identifies the tumor necrosis factor family member LIGHT as an essential mediator of airway fibrosis in a mouse model of chronic asthma (pages 596–603).

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Figure 1: Direct and indirect effects of LIGHT signaling in chronic asthma.

Marina Corral

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Correspondence to Thomas A Wynn.

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Wynn, T., Ramalingam, T. Shedding LIGHT on severe asthma. Nat Med 17, 547–548 (2011). https://doi.org/10.1038/nm0511-547

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