Moderate to severe asthma is difficult to treat because recurring bouts of inflammation in the lungs induce fibrosis, which reduces lung elasticity, gas exchange and responses to conventional therapy. A recent study identifies the tumor necrosis factor family member LIGHT as an essential mediator of airway fibrosis in a mouse model of chronic asthma (pages 596–603).
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References
- 1
Barnes, P.J. Nat. Rev. Immunol. 8, 183–192 (2008).
- 2
Moorman, J.E et al. MMWR Surveill. Summ. 56, 1–54 (2007).
- 3
Berry, M.A. et al. N. Engl. J. Med. 354, 697–708 (2006).
- 4
Doherty, T.A. et al. Nat. Med. 17, 596–603 (2011).
- 5
Mauri, D.N. et al. Immunity 8, 21–30 (1998).
- 6
Scheu, S. et al. J. Exp. Med. 195, 1613–1624 (2002).
- 7
Tamada, K. et al. Nat. Med. 6, 283–289 (2000).
- 8
Wang, J. et al. J. Clin. Invest. 108, 1771–1780 (2001).
- 9
Shaikh, R.B. et al. J. Immunol. 167, 6330–6337 (2001).
- 10
Minshall, E.M. et al. Am. J. Respir. Cell Mol. Biol. 17, 326–333 (1997).
- 11
de Boer, W.I. et al. Am. J. Respir. Crit. Care Med. 158, 1951–1957 (1998).
- 12
Wilson, M.S. & Wynn, T.A. Mucosal Immunol. 2, 103–121 (2009).
- 13
Woodruff, P.G. et al. Am. J. Respir. Crit. Care Med. 180, 388–395 (2009).
- 14
Ware, C.F. Annu. Rev. Immunol. 23, 787–819 (2005).
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Wynn, T., Ramalingam, T. Shedding LIGHT on severe asthma. Nat Med 17, 547–548 (2011). https://doi.org/10.1038/nm0511-547
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