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The B-side story in insulin resistance

Although leukocyte activation in fat tissue promotes obesity-related insulin resistance, a role for B cells has been unclear. A new study in obese mice shows that they enter the fat tissue to activate T cell function and boost inflammation, exacerbating the metabolic disease (pages 610–617).

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Figure 1: B cell cooperation with T cells and the release of antibodies mediates the pathogenesis of obesity-related insulin resistance.

Marina Corral


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Correspondence to Ziad Mallat.

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Mallat, Z. The B-side story in insulin resistance. Nat Med 17, 539–540 (2011).

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