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Revisiting Reproduction: Prematurity and the puzzle of progesterone resistance

Nature Medicine volume 16, pages 529–531 (2010)Cite this article

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Parturition is a complex and involved process. Within the protected confines of the mother, the fetus grows rapidly for 37–42 weeks until the right combination of signals, stemming from both endocrine and mechanical stimulation, induces parturition, culminating in birth. Aberrations in these signals may lead to prematurity or stillbirth.

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Figure 1: Molecular signaling in parturition.

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Authors and Affiliations

  1. Jeeyeon Cha and Sudhansu K. Dey are in the Division of Reproductive Sciences, Yasushi Hirota, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.,

    Yasushi Hirota, Jeeyeon Cha & Sudhansu K Dey

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  1. Yasushi Hirota
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  2. Jeeyeon Cha
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  3. Sudhansu K Dey
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Correspondence to Sudhansu K Dey.

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Hirota, Y., Cha, J. & Dey, S. Revisiting Reproduction: Prematurity and the puzzle of progesterone resistance. Nat Med 16, 529–531 (2010). https://doi.org/10.1038/nm0510-529

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