T cell receptors and cancer: gain gives pain

T lymphocytes engineered to produce T cell receptors specific for tumor antigens lead to an antitumor immune response. New findings draw attention to a potentially deadly problem with this strategy. The transgenic T cell receptors can shuffle components with native receptors to produce hybrid molecules with specificity against self antigens (pages 565–570).

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Figure 1: Cross-pairing risk of transgenic T cell receptors.

Kimberly Caesar

Change history

  • 07 June 2010

     In the version of this News and Views initially published, the last name of one of the authors whose work was being discussed, Gavin M. Bendle, was incorrectly written as ‘Bender’ in three places. The error has been corrected in the HTML and PDF versions of the article.

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Correspondence to Malcolm Brenner.

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Brenner, M. T cell receptors and cancer: gain gives pain. Nat Med 16, 520–521 (2010). https://doi.org/10.1038/nm0510-520

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