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Reply to: “β-catenin does not regulate memory T cell phenotype”

Nature Medicine volume 16, pages 514–515 (2010)Cite this article

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Gattinoni, Ji and Restifo reply:

We recently reported that the activation of the Wnt–β-catenin pathway during T cell priming arrests effector T cell differentiation and promotes the generation of CD8+ memory stem cells (TSCM cells), which we found to be more effective than other memory T cell subsets in treating tumors in mice after adoptive cell transfer1. We generated TSCM cells by activating naive CD8+ T cells in the presence of a naturally occurring ligand, Wnt3a, or inhibitors of glycogen synthase kinase-β (GSK-3β) to stabilize β-catenin and mimic downstream events of the Wnt signaling cascade.

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Figure 1: Wnt3a stabilizes β-catenin in primed CD8+ T cells.

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Acknowledgements

This research was supported by the Intramural Research Program of the US National Institutes of Health, National Cancer Institute, Center for Cancer Research. We would like to thank W. Held and J. Misra Sen for helpful discussion and critical review of this correspondence.

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  1. US National Institutes of Health, National Cancer Institute, Bethesda, Maryland, USA

    Luca Gattinoni, Yun Ji & Nicholas P Restifo

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  1. Luca Gattinoni
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  2. Yun Ji
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  3. Nicholas P Restifo
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Correspondence to Nicholas P Restifo.

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Gattinoni, L., Ji, Y. & Restifo, N. Reply to: “β-catenin does not regulate memory T cell phenotype”. Nat Med 16, 514–515 (2010). https://doi.org/10.1038/nm0510-514

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