Studies of schizophrenia have been plagued by shortcomings such as weak genetic association with disease, inadequate animal models and limited replication of gene expression findings. Future success may lie not in overcoming any one of these limitations but in a broad approach strengthening the evidence in each area. Using such an approach, neuroscientists have uncovered a new gene behind the disease (pages 509–518).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Huffaker, S.J. et al. Nat. Med. 15, 509–518 (2009).
Lewis, D.A. & Lieberman, J.A. Neuron 28, 325–334 (2000).
Owen, M.J., Craddock, N. & O'Donovan, M.C. Trends Genet. 21, 518–525 (2005).
Harrison, P.J. & Weinberger, D.R. Mol. Psychiatry 10, 40–68 (2005).
Chanock, S.J. et al. Nature 447, 655–660 (2007).
Mirnics, K. & Pevsner, J. Nat. Neurosci. 7, 434–439 (2004).
Insel, T.R. Biol. Psychiatry 62, 1337–1339 (2007).
Moore, A.F. & Florez, J.C. Annu. Rev. Med. 59, 95–111 (2008).
Grigoriadis, D.E., Hoare, S.R., Lechner, S.M., Slee, D.H. & Williams, J.A. Neuropsychopharmacology 34, 106–125 (2009).
Schimpf, R., Borggrefe, M. & Wolpert, C. Curr. Opin. Cardiol. 23, 192–198 (2008).
Glassman, A.H. J. Clin. Psychiatry 66 Suppl 6, 5–10 (2005).
Conn, P.J. & Roth, B.L. Neuropsychopharmacology 33, 2048–2060 (2008).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Horváth, S., Mirnics, K. Breaking the gene barrier in schizophrenia. Nat Med 15, 488–490 (2009). https://doi.org/10.1038/nm0509-488
Issue Date:
DOI: https://doi.org/10.1038/nm0509-488
This article is cited by
-
Neurodevelopment, GABA System Dysfunction, and Schizophrenia
Neuropsychopharmacology (2015)
-
Modulation of behavioral networks by selective interneuronal inactivation
Molecular Psychiatry (2014)