Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

β-adrenergic signaling in heart failure—adapt or die

About 25% of the African-American population carries a gene variant that seems to protect against heart failure. The findings may have implications for the use of β-blockers (pages 510–517).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Vicious cycle in heart failure.

Kim Caesar

References

  1. Liggett, S.B. et al. Nat. Med. 14, 510–517 (2008).

    Article  CAS  Google Scholar 

  2. Waagstein, F., Hjalmarson, A., Varnauskas, E. & Wallentin, I. Br. Heart J. 37, 1022–1036 (1975).

    Article  CAS  Google Scholar 

  3. Collins, S. et al. Biochem. Soc. Trans. 18, 541–544 (1990).

    Article  CAS  Google Scholar 

  4. Lohse, M.J., Engelhardt, S. & Eschenhagen, T. Circ. Res. 93, 896–906 (2003).

    Article  CAS  Google Scholar 

  5. Bristow, M.R. et al. N. Engl. J. Med. 307, 205–211 (1982).

    Article  CAS  Google Scholar 

  6. El-Armouche, A., Pamminger, T., Ditz, D., Zolk, O. & Eschenhagen, T. Cardiovasc. Res. 61, 87–93 (2004).

    Article  CAS  Google Scholar 

  7. Ungerer, M., Bohm, M., Elce, J.S., Erdmann, E. & Lohse, M.J. Circulation 87, 454–463 (1993).

    Article  CAS  Google Scholar 

  8. Feldman, A.M. et al. J. Clin. Invest. 82, 189–197 (1988).

    Article  CAS  Google Scholar 

  9. Faulx, M.D. et al. Am. J. Physiol. Heart Circ. Physiol. 289, H30–H36 (2005).

    Article  CAS  Google Scholar 

  10. Reihsaus, E., Innis, M., MacIntyre, N. & Liggett, S.B. Am. J. Respir. Cell Mol. Biol. 8, 334–339 (1993).

    Article  CAS  Google Scholar 

  11. Liggett, S.B. Am. J. Med. 117, 525–527 (2004).

    Article  Google Scholar 

  12. Brodde, O.E. Pharmacol. Ther. 117, 1–29 (2008).

    Article  CAS  Google Scholar 

  13. Gainetdinov, R.R. et al. Neuron 24, 1029–1036 (1999).

    Article  CAS  Google Scholar 

  14. Walker, J.K. et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 286, L312–L319 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eschenhagen, T. β-adrenergic signaling in heart failure—adapt or die. Nat Med 14, 485–487 (2008). https://doi.org/10.1038/nm0508-485

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0508-485

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing