The presence of autophagic morphology in failing heart muscle cells has suggested that autophagy causes heart failure. Instead, it seems that the opposite is true: autophagy is critical for normal heart function (pages 619–624).
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References
Cuervo, A.M. Trends Cell Biol. 14, 70–77 (2004).
Tsujimoto, Y. & Shimizu, S. Cell Death Differ. 12 (suppl. 2), 1528–1534 (2005).
Shimomura, H. et al. Jpn. Circ. J. 65, 965–968 (2001).
Miyata, S. et al. Am. J. Pathol. 168, 386–397 (2006).
Nakai, A. et al. Nat. Med. 13, 619–624 (2007).
Hamacher-Brady, A., Brady, N.R. & Gottlieb, R.A. J. Biol. Chem. 281, 29776–29787 (2006).
Matsui, Y., et al. Circ. Res. 100, 914–922 (2007).
Komatsu, M. et al. J. Cell Biol. 169, 425–434 (2005).
Komatsu, M. et al. Nature 441, 880–884 (2006).
Hara, T. et al. Nature 441, 885–889 (2006).
Massey, A.C., Kaushik, S., Sovak, G., Kiffin, R. & Cuervo, A.M. Proc. Natl. Acad. Sci. USA 103, 5905–5910 (2006).
Iwata, A., Riley, B.E., Johnston, J.A. & Kopito, R.R. J. Biol. Chem. 280, 40282–40292 (2005).
Tanaka, Y. et al. Nature 406, 902–906 (2000).
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Kitsis, R., Peng, CF. & Cuervo, A. Eat your heart out. Nat Med 13, 539–541 (2007). https://doi.org/10.1038/nm0507-539
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DOI: https://doi.org/10.1038/nm0507-539
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