Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The bridge between dendritic cells and asthma

Nature Medicine volume 13, pages 536–538 (2007)Cite this article

A single molecule, osteopontin, seems to both amplify and quell the immune response in asthma—depending on the stage of the asthmatic reaction. The findings hint that, if given at the right stage, osteopontin might have value as a therapy (pages 570–578).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Regulation of dendritic cell migration in airway hypersensitivity (AHR) by Opn-s.

Kim Caesar

References

  1. Oldberg, A., Franzen, A., Heinegard, D., Pierschbacher, M. & Ruohslahti, E. J. Biol. Chem. 263, 19433–19436 (1988).

    CAS  PubMed  Google Scholar 

  2. Patarca, R. et al. J. Exp. Med. 170, 145–161 (1989).

    Article  CAS  Google Scholar 

  3. Nau, G.J. et al. Am. J. Pathol. 157, 37–42 (2000).

    Article  CAS  Google Scholar 

  4. Zandman-Goddard, G. & Shoenfeld, Y. Clin. Rev. Allergy Immunol. 25, 29–40 (2003).

    Article  Google Scholar 

  5. Ashkar, S. et al. Science 287, 860–864 (2000).

    Article  CAS  Google Scholar 

  6. Weiss, J.M. et al. J. Exp. Med. 194, 1219–1230 (2001).

    Article  CAS  Google Scholar 

  7. Xanthou, G. et al. Nat. Med. 13, 570–578 (2007).

    Article  CAS  Google Scholar 

  8. de Heer, H.J. et al. J. Exp. Med. 200, 89–98 (2004).

    Article  CAS  Google Scholar 

  9. Lambrecht, B.N. et al. J. Clin. Invest. 106, 551–559 (2000).

    Article  CAS  Google Scholar 

  10. Shinohara, M.L. et al. Nat. Immunol. 7, 498–506 (2006).

    Article  CAS  Google Scholar 

  11. Zhu, B. et al. J. Cell. Physiol. 198, 155–167 (2004).

    Article  CAS  Google Scholar 

  12. Nystrom, T., Duner, P. & Hultgardh-Nilsson, A. Exp. Cell Res. 313, 1149–1160 (2007).

    Article  Google Scholar 

  13. Begum, M.D. et al. Microbiol. Immunol. 51, 135–147 (2007).

    Article  CAS  Google Scholar 

  14. Steinman, L., Martin, R., Bernard, C., Conlon, P. & Oksenberg, J.R. Annu. Rev. Neurosci. 25, 491–505 (2002).

    Article  CAS  Google Scholar 

  15. Ohsuzu, F. J. Atheroscler. Thromb. 11, 313–321 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cancer Immunology & AIDS, and the Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Mari L Shinohara & Harvey Cantor

Authors
  1. Mari L Shinohara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harvey Cantor
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shinohara, M., Cantor, H. The bridge between dendritic cells and asthma. Nat Med 13, 536–538 (2007). https://doi.org/10.1038/nm0507-536

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0507-536

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing