Titin is a massive protein that provides mechanical and structural support in striated muscles. Titin is now implicated in a new signaling pathway that seems to control gene expression. Loss of this pathway as a result of a mutation in titin leads to hereditary muscle disease.
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References
Lange, S. et al. Science 31 March 2005 (10:1126/science. 1110463).
Horowits, R., Kempner, E.S., Bisher, M.E. & Podolsky, R.J. Nature 323, 160–164 (1986).
Burkholder, T.J. & Lieber, R.L. J. Exp. Biol. 204, 1529–1536 (2001).
Granzier, H. & Labeit, S. Circ. Res. 94, 284–295 (2004).
Miller, M.K., Granzier, H., Ehler, E. & Gregorio, C.C. Trends Cell Biol. 14, 119–126 (2004).
Hein, S. & Schaper, J. Trends Mol. Med. 8, 311–313 (2002).
Mayans, O. et al. Nature 395, 863–869 (1998).
Grater, F., Shen, J. Jiang, H., Gautel, M. & Grubmuller, H. Biophys. J. 88, 790–804 (2005).
Edstrom, L. Thornell, L.E., Albo, J. Landin, S. & Samuelson, M. J. Neurol Sci. 96, 211–228 (1990).
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Tskhovrebova, L., Trinick, J. Muscle disease: a giant feels the strain. Nat Med 11, 478–479 (2005). https://doi.org/10.1038/nm0505-478
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DOI: https://doi.org/10.1038/nm0505-478
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