The lipid mediator ceramide contributes to tissue destruction in emphysema by promoting apoptosis of structural cells in the lung. This finding challenges a traditional hypothesis for the pathogenesis of emphysema (pages 491–498).
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Ann Thomsom
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Elias, J., Lee, C. Lipid let loose in pulmonary emphysema. Nat Med 11, 471–472 (2005). https://doi.org/10.1038/nm0505-471
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DOI: https://doi.org/10.1038/nm0505-471
