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Calcium and heart failure: the cycle game

Nature Medicine volume 9, pages 508–509 (2003)Cite this article

Three new studies examine how a regulator of calcium homeostasis contributes to heart failure in humans and mice.

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Figure 1: Sarcoplasmic reticulum (SR) calcium cycling.

References

  1. Schmitt, J.P. et al. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science 299, 1410–1413 (2003).

    Article  CAS  Google Scholar 

  2. Haghighi, K. et al. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J. Clin. Invest. 111, 869–876 (2003).

    Article  CAS  Google Scholar 

  3. Song, Q. et al. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J. Clin. Invest. 111, 859–867 (2003).

    Article  CAS  Google Scholar 

  4. Tada, M. & Toyofuku, T. Molecular regulation of phospholamban function and expression. Trends Cardiovasc. Med. 8, 330–340 (1998).

    Article  CAS  Google Scholar 

  5. Hasenfuss, G. & Pieske, B. Calcium cycling in congestive heart failure. J. Mol. Cell. Cardiol. 34, 951–969 (2002).

    Article  CAS  Google Scholar 

  6. Marx, S.O. et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101, 365–376 (2000).

    Article  CAS  Google Scholar 

  7. Minamisawa, S. et al. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99, 313–322 (1999).

    Article  CAS  Google Scholar 

  8. Sato, Y. et al. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. J. Biol. Chem. 276, 9392–9399 (2001).

    Article  CAS  Google Scholar 

  9. Freeman, K. et al. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J. Clin. Invest. 107, 967–974 (2001).

    Article  CAS  Google Scholar 

  10. Hoshijima, M. et al. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat. Med. 8, 864–871 (2002).

    Article  CAS  Google Scholar 

  11. del Monte, F., Harding, S.E., Dec, G.W., Gwathmey, J.K. & Hajjar, R.J. Targeting phospholamban by gene transfer in human heart failure. Circulation 105, 904–907 (2002).

    Article  CAS  Google Scholar 

  12. Chien, K.R. Genomic circuits and the integrative biology of cardiac diseases. Nature 407, 227–232 (2000).

    Article  CAS  Google Scholar 

  13. Towbin, J.A. & Bowles, N.E. The failing heart. Nature 415, 227–233 (2002).

    Article  CAS  Google Scholar 

  14. Toyoshima, C. et al. Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase. Proc. Natl. Acad. Sci. USA 100, 467–472 (2003).

    Article  CAS  Google Scholar 

  15. Knoll, R. et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111, 943–955 (2002).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. University of California, San Diego Institute of Molecular Medicine, UCSD School of Medicine, La Jolla, California, USA

    Kenneth R. Chien, John Ross Jr. & Masahiko Hoshijima

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  1. Kenneth R. Chien
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  2. John Ross Jr.
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  3. Masahiko Hoshijima
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Correspondence to Kenneth R. Chien.

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Chien, K., Ross, J. & Hoshijima, M. Calcium and heart failure: the cycle game. Nat Med 9, 508–509 (2003). https://doi.org/10.1038/nm0503-508

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