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References
McMahon, T.J. et al. Nitric oxide in the human respiratory cycle. Nat. Med. 8, 711–717 (2002).
Rassaf, T. et al. Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical study on the fate of NO in human blood. Circ. Res. 91, 470–477 (2002).
Jia, L., Bonaventura, C., Bonaventura, J. & Stamler, J.S. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 380, 221–226 (1996).
Feelisch, M. et al. Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. FASEB J. 16, 1775–1785 (2002).
Rassaf, T., Bryan, N.S., Kelm, M. & Feelisch, M. Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic. Biol. Med. 33, 1590–1596 (2002).
Wennmalm, A. et al. Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ. Res. 73, 1121–1127 (1993).
Cantilena, L.R. et al. Nitric oxide hemoglobin in patients receiving nitroglycerin as detected by electron paramagnetic resonance spectroscopy. J. Lab. Clin. Med. 120, 902–907 (1992).
Miranda J.J. Highly reactive cysteine residues in rodent hemoglobins. Biochem. Biophys. Res. Commun. 275, 517–523 (2000).
Rossi, R. et al. Fast-reacting thiols in rat hemoglobins can intercept damaging species in erythrocytes more efficiently than glutathione. J. Biol. Chem. 273, 19198–19206 (1998).
Hobbs, A.J., Gladwin, M.T., Patel, R.P., Williams, D.L. & Butler, A.R. Haemoglobin: NO transporter, NO inactivator or NOne of the above? Trends Pharmacol. Sci. 23, 406–411 (2002).
Luchsinger, B.P. et al. Routes to S-nitroso-hemoglobin formation with heme redox and preferential reactivity in the β subunits. Proc. Natl. Acad. Sci. USA 100, 461–466 (2003).
Mamone, G., Sannolo, N., Malorni, A. & Ferranti, P. In vitro formation of S-nitrosohemoglobin in red cells by inducible nitric oxide synthase. FEBS Lett. 462, 241–245 (1999).
Roccatello, D. et al. Early increase in blood nitric oxide, detected by electron paramagnetic resonance as nitrosylhaemoglobin, in hemodialysis. Nephrol. Dial. Transplant 12, 292–297 (1997).
Kirima, K. et al. Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO. Am. J. Physiol. Heart Circ. Physiol., 27 March 2003 (DOI 10.1152/ajpheart. 01010.2002).
Takahashi, Y. et al. Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation. Am. J. Physiol. Heart Circ. Physiol. 274, H349–H357 (1998).
Gonzalez-Alonso, J., Richardson, R.S. & Saltin, B. Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen. J. Physiol. 530, 331–341 (2001).
Stamler, J.S. et al. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 276, 2034–2037 (1997).
Dietrich, H.H., Ellsworth, M.L., Sprague, R.S. & Dacey, R.G. Red blood cell regulation of microvascular tone through adenosine triphosphate. Am. J. Physiol. Heart Circ. Physiol. 278, H1294–H1298 (2000).
Gorczynski, R.J. & Duling, B.R. Role of oxygen in arteriolar functional vasodilation in hamster striated muscle. Am. J. Physiol. 235, H505–H515 (1978).
Kashiwagi, S., Kajimura, M., Yoshimura, Y. & Suematsu, M. Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography. Circ. Res. 91, e55–e64 (2002).
Gladwin, M.T. et al. Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proc. Natl. Acad. Sci. USA 97, 9943–9948 (2000).
Pawloski, J.R., Hess, D.T. & Stamler, J.S. Export by red blood cells of nitric oxide bioactivity. Nature 409, 622–626 (2001).
Gow, A.J. & Stamler, J.S. Reactions between nitric oxide and haemoglobin under physiological conditions. Nature 391, 169–173 (1998).
McMahon, T.J., Stone, A.E., Bonaventura, J., Singel, D.J. & Stamler, J.S. Functional coupling of oxygen-binding and vasoactivity in S-nitrosohemoglobin. J. Biol. Chem. 275, 16738–16745 (2000).
Herold, S. & Rock, G. Reactions of deoxy-, oxy-, and methemoglobin with nitrogen monoxide. Mechanistic studies of the S-nitrosothiol formation under different mixing conditions. J. Biol. Chem. 278, 6623–6634 (2003).
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Stamler, J., Hess, D. & Singel, D. Reply to "NO adducts in mammalian red blood cells: too much or too little?". Nat Med 9, 482–483 (2003). https://doi.org/10.1038/nm0503-482
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DOI: https://doi.org/10.1038/nm0503-482