The mutant proteins that cause polyglutamine disease bind CREB-binding protein (CBP), a key transcriptional co-activator for neuronal survival factors. This results in a loss of CBP-dependent transcription and may account for the neuronal degeneration associated with these diseases.
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About this article
Cellular and Molecular Life Sciences (2018)
Neurobiology of Disease (2018)
Molecular Neurobiology (2018)
Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology
The FEBS Journal (2016)