Polyglutamine and CBP: Fatal attraction?

The mutant proteins that cause polyglutamine disease bind CREB-binding protein (CBP), a key transcriptional co-activator for neuronal survival factors. This results in a loss of CBP-dependent transcription and may account for the neuronal degeneration associated with these diseases.

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Figure 1: Nuclear factor sequestration in polyglutamine disease.

Renee Lucas

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