COX-2 selective non-steroidal anti-inflammatory drugs show promise in the prevention of coiorectal cancer and possibly other tumors.
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References
- 1
Shift, S.J. & Rigas, B. Nonsteroidal antiinflamma-tory drugs and colorectal cancer: evolving concepts of their chemopreventive actions. Gastroenterology 113 1992–1998 (1997).
- 2
Kawamori, T., Rao, C.V., Seibert, K. & Reddy, B.S. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res. 58, 409–412 (1998).
- 3
Williams, C.S. & DuBois, R.N. Prostaglandin endoperoxide synthase: Why two isoforms? Am. J. Physiol 270, G393–G400 (1996).
- 4
Oshima, M. et al. Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803–809 (1996).
- 5
Sheng, H., Shao, J., Morrow, J.D., Beauchamp, R.D. & DuBois, R.N. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 58, 362–366 (1998).
- 6
Chan, T.A., Morin, P.J., Vogelstein, B. & Kinzler, K.W. Mechanisms underlying nonsteroidal anti-inflammatory drug-mediated apoptosis. Proc. Natl. Acad. Sci. USA 95, 681–686 (1998).
- 7
Piazza, G.A. et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res. 57, 2909–2915 (1997).
- 8
Elder, D.J.E., Halton, D.E., Hague, A. & Paraskeva, C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. Clin. Can. Res. 3, 1679–1683 (1997).
- 9
Vane, J. Towards a better aspirin. Nature 367, 215–216 (1994).
- 10
Hong, S.H. et al. Regulation of head and neck tumor cell growth with cyclooxygenase-2 specific inhibitor, ketorolac. Cancer Res. 39, 196 (1998).
- 11
Hwang, D. et al. Expression of cyclooxygenase in human breast cancer. Cancer Res. 39, 353 (1998).
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Elder, D., Paraskeva, C. COX-2 inhibitors for colorectal cancer. Nat Med 4, 392–393 (1998). https://doi.org/10.1038/nm0498-392
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