Although the most severe Herpes Simplex Virus-related symptoms seem to occur in patients with impaired cell-mediated immunity, until recently it appeared that patients who seemed to better control the infection showed little by way of anti-HSV cytotoxic T lymphocyte responses. Lawrence Corey and colleagues explain.
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Posavad, C., Koelle, D. & Corey, L. Tipping the scales of herpes simplex virus reactivation: The important responses are local. Nat Med 4, 381–382 (1998). https://doi.org/10.1038/nm0498-381
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DOI: https://doi.org/10.1038/nm0498-381
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