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HIV-1 antibody — debris or virion?

Nature Medicine volume 3, pages 366–367 (1997)Cite this article

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References

  1. Barbas, C.F. et al. Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries. J. Mol. Biol. 230, 812–823 (1993).

    Article  CAS  PubMed  Google Scholar 

  2. Ditzel, H.J. et al. Mapping the protein surface of HIV-1 gp120 using human monoclonal antibodies from phage display libraries. J. Mol. Biol. 267, 684–695 (1997).

    Article  CAS  PubMed  Google Scholar 

  3. Earl, P.L. et al. Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol. 68, 3015–3026 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Parren, P.W.H.I. et al. In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope. J. Virol. 70, 9046–9050 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Roben, P. et al. Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J. Virol. 68, 4821–4828 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Sattentau, Q.J. & Moore, J.P. Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer. J. Exp. Med. 182, 185–196 (1995).

    Article  CAS  PubMed  Google Scholar 

  7. D'Souza, M.P. et al. Evaluation of monoclonal antibodies to HIV-1 primary isolates by neutralization assays: performance criteria for selecting candidate antibodies for clinical trials. J. Infect. Dis. 175, 1056–1062 (1997).

    Article  CAS  PubMed  Google Scholar 

  8. Willey, R.L. et al. Biosynthesis, cleavage and degradation of the human immunodeficiency virus type 1 envelope glycoprotein gp160. Proc. Natl. Acad. Sci. USA 85, 9580–9584 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Davenport, F.M. & Hennessy, A.V. Predetermination by infection and by vaccination of antibody response to influenza virus vaccines. J. Exp. Med. 106, 835–850 (1957).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. The Scripps Research Institute, Departments of Immunology and Molecular Biology, 10550 North Torrey Pines Road (IMM2), La Jolla, California, 92037, USA

    Paul W.H.I. Parren & Dennis R. Burton

  2. a Scholar of the Pediatric AIDS Foundation,

    Paul W.H.I. Parren

  3. Centre d'Immunologie de Marseille-Luminy, Case 906, 13288, Marseille, France

    Quentin J. Sattentau

Authors
  1. Paul W.H.I. Parren
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  2. Dennis R. Burton
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  3. Quentin J. Sattentau
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Correspondence to Dennis R. Burton.

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Parren, P., Burton, D. & Sattentau, Q. HIV-1 antibody — debris or virion?. Nat Med 3, 366–367 (1997). https://doi.org/10.1038/nm0497-366d

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