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Axonal injury in reverse

Axonal damage causes neurological defects in multiple sclerosis. In vivo imaging in mouse models of multiple sclerosis now shows a reversible and sequential process of focal axonal degeneration (FAD) (pages 495–499), suggesting the use of neuroregenerative as well as neuroprotective drugs as potential therapies for multiple sclerosis.

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Figure 1: Focal axonal degeneration in inflammatory diseases of the CNS.

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Correspondence to Lars Fugger.

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Craner, M., Fugger, L. Axonal injury in reverse. Nat Med 17, 423–425 (2011). https://doi.org/10.1038/nm0411-423

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