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Bad Blood: A trigger for TRALI

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  1. Hillyer, C.D., Silberstein, L., Ness, P., Anderson, K. & Roback, J. Blood Banking and Transfusion Medicine. Ch. 8, 95–110 (Churchill Livingstone, Philadelphia, 2006).

    Google Scholar 

  2. Popovsky, M.A., Chaplin, H.C. Jr. & Moore, S.B. Transfusion 32, 589–592 (1992).

    Article  CAS  Google Scholar 

  3. Greinacher, A. et al. Nat. Med. 16, 45–48 (2010).

    Article  CAS  Google Scholar 

  4. Curtis, B.R. et al. Blood 115, 2073–2076 (2010).

    Article  CAS  Google Scholar 

  5. Kelher, M.R. et al. Blood 113, 2079–2087 (2009).

    Article  CAS  Google Scholar 

  6. Looney, M.R. et al. J. Clin. Invest. 119, 3450–3461 (2009).

    PubMed  PubMed Central  Google Scholar 

  7. Hidalgo, A. et al. Nat. Med. 15, 384–391 (2009).

    Article  CAS  Google Scholar 

  8. Silliman, C.C., Fung, Y.L., Ball, J.B. & Khan, S.Y. Blood Rev. 23, 245–255 (2009).

    Article  Google Scholar 

  9. Bux, J. Vox Sang. 94, 277–285 (2008).

    Article  CAS  Google Scholar 

  10. Van Leeuwen, A., Eernisse, J.G. & Van, R. Vox Sang. 9, 431–446 (1964).

    Article  CAS  Google Scholar 

  11. Blusztajn, J.K. Science 281, 794–795 (1998).

    Article  CAS  Google Scholar 

  12. Traiffort, E., Ruat, M., O'Regan, S. & Meunier, F.M. J. Neurochem. 92, 1116–1125 (2005).

    Article  CAS  Google Scholar 

  13. Nair, T.S. et al. J. Neurosci. 24, 1772–1779 (2004).

    Article  CAS  Google Scholar 

  14. Chapman, C.E. et al. Transfusion 49, 440–452 (2009).

    Article  Google Scholar 

Download references

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Correspondence to Paul S Frenette.

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P.S.F. has served as a consultant for Glycomimetics.

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Frenette, P., Mohandas, N. Bad Blood: A trigger for TRALI. Nat Med 16, 382–383 (2010).

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